Evolution of ligand specificity in vertebrate corticosteroid receptors
Abstract Background Corticosteroid receptors include mineralocorticoid (MR) and glucocorticoid (GR) receptors.Teleost fishes have a single MR and duplicate GRs that show variable sensitivities to mineralocorticoids and glucocorticoids.How these receptors compare functionally to tetrapod MR and GR, and the evolutionary significance of maintaining tw